Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives

The clinical pharmacology of lidocaine as an antiarrhythymic drug.

This article reviews current knowledge about lidocaine, with reference to its chemistry, metabolism, electrophysiology, hemodynamic effects, antiarrhythmic uses, pharmacokinetics, and side effects. The critical importance of blood levels and their relation to lidocaine's antiarrhythmic and toxic effects is noted, with special emphasis given to patients with compromised clearance due to heart fa...

Perspectives in Pharmacology Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development

The specific pharmacological response evoked by a nicotinic acetylcholine receptor (nAChR) agonist is governed by the anatomical distribution and expression of each receptor subtype and by the stoichiometry of subunits comprising each subtype. Contributing to this complexity is the ability of agonists that bind to the orthosteric site of the receptor to alter the affinity state of the receptor ...

Clinical drug development--practical issues in clinical pharmacology studies.

INTRODUCTION Clinical pharmacology refers to the study of the safety, pharmacodynamic activity, mechanism of action, pharmacokinetics, metabolism and excretion of a drug in man. METHODS Selected review of topics that provide guidance on practical issues for researchers conducting non-therapeutic investigational research in humans. RESULTS Close attention to the issues highlighted is needed ...

The importance of clinical pharmacology in drug development.

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...